Oss, June 22nd 2017 – Today NTRC has launched an expansion of its Oncolines™ cancer cell line panel, from 66 to 102 cell lines. Oncolines™ are proliferation assays on a panel of genetically well-characterized cancer cell lines from diverse tumor tissue origin. NTRC has a commercial license from the American Type Culture Collection (ATCC). Oncolines™ profiling includes genomic biomarker analysis and comparative profiling against a library of more than 150 pre-profiled anti-cancer agents. In recent publications in Molecular Cancer Therapeutics [1] and Nature Communications [2] the reproducibility of Oncolines™ cell panel profiling and its application in mechanism-of-action studies has been demonstrated. The Oncolines™ biomarker analysis can be extended with gene expression analysis through GeneNominator™.

Characteristics Oncolines™:
– Readout ATPlite™
– Low passage number and ATCC recommended culturing conditions
– No IC50 extrapolation
– 384-well, automated liquid handling
– Manual inspection of curves

Recent publications with Oncolines™ and OncolinesProfiler™ results:
[1] Uitdehaag et al. (2016) Cell panel profiling reveals conserved therapeutic clusters and differentiates the mechanism of action of different PI3K/mTOR, Aurora kinase and EZH2 inhibitors. Molecular Cancer Therapeutics 15, 3097-3109
[2] Bohnacker et al. (2017) Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nature Communication 8:14683

For more information or quotations, please sent e-mail to services@ntrc.nl

About NTRC
NTRC is a precision medicine company dedicated to the development of new anti-cancer drugs. NTRC facilitates the development of novel therapies by providing cancer cell line profiling services (Oncolines™, OncolinesProfiler™, and SynergyFinder™) and target residence time measurements for protein kinases (ResidenceTimer™) on a fee-for-service basis. NFK GreenScreen™, an assay read-out for the cancer immunotherapy drug targets IDO1 and TDO, is supplied to clients globally. For more information please visit www.ntrc.nl or contact info@ntrc.nl